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伴有自杀意念的双相情感障碍患者前额叶 磁共振波谱研究
陈佳悦邹韶红曲源郑惠文任永芳
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目的 借助氢质子磁共振波谱检测手段探讨双相情感障碍患者自杀意念与前额叶各代谢 物之间的关系。方法 2017 年 4 月至 2019 年 8 月收集新疆维吾尔自治区人民医院临床心理科 21 例 1 个 月内未经治疗的双相情感障碍患者,按有无自杀意念分为有自杀意念组(12 例)与无自杀意念组(9 例), 应用氢质子磁共振波谱技术分别检测两组左右侧前额叶 N- 乙酰天门冬氨酸 / 肌酸(NAA/Cr)、胆碱 / 肌 酸(Cho/Cr)、谷氨酸和谷氨酰胺复合物 / 肌酸(Glx/Cr)、肌醇 / 肌酸(mI/Cr)的比值。结果 有自杀意念的 双相情感障碍患者组右侧前额叶 mI/Cr 值高于无自杀意念的双相情感障碍患者组,差异有统计学意义 (P< 0.05);两组在左右侧前额叶 NAA/Cr 值、Cho/Cr 值、Glx/Cr 值及左侧前额叶 mI/Cr 值的比较中差异均 无统计学意义(P> 0.05);有自杀意念的双相情感障碍患者组左侧前额叶 mI/Cr 值与发病年龄呈正相关 (r=0.661,P< 0.05)。结论 有自杀意念的双相情感障碍患者右侧前额叶肌醇代谢水平增高;有自杀意 念的双相情感障碍患者发病年龄越大,左侧前额叶肌醇代谢水平就会越高
基金项目:新疆维吾尔自治区自然科学基金(2017D01C109)
A study on the magnetic resonance spectroscopy of frontal lobe in patients with bipolar disorder with suicidal ideation
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Abstract:
Objective Using proton magnetic resonance spectroscopy to explore the relationship between suicidal ideation and metabolites of prefrontal lobes in bipolar disorder patients. Methods A total of 21 patients with untreated bipolar disorder in one month were divided into suicidal ideation group (12 cases) and non-suicidal ideation group (9 cases) in People's Hospital of Xinjiang Uygur Autonomous Region from April 2017 to August 2019. The ratios of N-acetylasparte/creatine (NAA/Cr), choline/creatine (Cho/Cr), glutamic acid and glutamine complex/creatine (Glx/Cr), myo-inositol/creatine (mI/Cr) in the left and right prefrontal lobes of the two groups were measured by proton magnetic resonance spectroscopy. Results The right prefrontal cortex mI/Cr ratios of bipolar disorder patients with suicidal ideation was higher than that of bipolar disorder patients without suicidal ideation (P< 0.05). The NAA/Cr, Cho/Cr and Glx/Cr ratios in the right and left frontal lobes and mI/Cr ratios in left prefrontal lobe of the two groups showed no statistically significant differences (P> 0.05). The mI/ Cr ratios of left prefrontal lobe was positively correlated with age of onset in patients with bipolar disorder with suicidal ideation (r=0.661,P< 0.05). Conclusions Patients with bipolar disorder with suicidal ideation have increased levels of inositol metabolism in the right prefrontal lobe. The older the patients with bipolar disorder with suicidal ideation are, the more significant the level of inositol metabolism in the left prefrontal lobe is.

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